Estudios sobre Células madre

Most advanced Stem cells and Stem cell therapy. Stem Cells Colombia, Células madre Medellín Colombia

Estudios sobre Células madre

Algunas referencias bibliográficas e investigación científica con estudios sobre células madre y exosomas derivados de células madre y sus aplicaciones para tratar diferentes patologías. 

Presentamos algunos estudios sobre células madre dirigidos a conocer los mecanismos de acción en el sistema inmune y en células y tejidos del cuerpo tanto en laboratorio como en aplicaciones terapeuticas.

Los estudios presentados a continuación están escritos en español e inglés.

Stem Cell provider with advanced stem cell research and development.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100822/

https://pubmed.ncbi.nlm.nih.gov/35441799/

Scientific Literature on Stem cell Research in english:

References

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33. Hasselblatt P, et al. Remission of refractory Crohn’s disease by high-dose cyclophosphamide and autologous peripheral blood stem cell transplantation. Aliment Pharm. Ther. 2012;36:725–735. doi: 10.1111/apt.12032. [PubMed] [CrossRef] []
34. Hawkey CJ, et al. Autologous hematopoetic stem cell transplantation for refractory Crohn disease: a randomized clinical trial. J. Am. Med. Assoc. 2015;314:2524–2534. doi: 10.1001/jama.2015.16700. [PubMed] [CrossRef] []
35. Lindsay JO, et al. Autologous stem-cell transplantation in treatment-refractory Crohn’s disease: an analysis of pooled data from the ASTIC trial. Lancet Gastroenterol. Hepatol. 2017;2:399–406. doi: 10.1016/S2468-1253(17)30056-0. [PubMed] [CrossRef] []
36. Wang R, et al. Stem cell therapy for Crohn’s disease: systematic review and meta-analysis of preclinical and clinical studies. Stem Cell Res Ther. 2021;12:463. doi: 10.1186/s13287-021-02533-0. [PMC free article] [PubMed] [CrossRef] []
37. Hawkey CJ. Hematopoietic stem cell transplantation in Crohn’s disease: state-of-the-art treatment. Dig. Dis. 2017;35:107–114. doi: 10.1159/000449090. [PubMed] [CrossRef] []
38. Si-Tayeb K, Lemaigre FP, Duncan SA. Organogenesis and development of the liver. Dev. Cell. 2010;18:175–189. doi: 10.1016/j.devcel.2010.01.011. [PubMed] [CrossRef] []
39. Xue R, et al. Clinical performance of stem cell therapy in patients with acute-on-chronic liver failure: a systematic review and meta-analysis. J. Transl. Med. 2018;16:126. doi: 10.1186/s12967-018-1464-0. [PMC free article] [PubMed] [CrossRef] []
40. Shi M, et al. Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients. Stem Cells Transl. Med. 2012;1:725–731. doi: 10.5966/sctm.2012-0034. [PMC free article] [PubMed] [CrossRef] []
41. Liu Y, Dong Y, Wu X, Xu X, Niu J. The assessment of mesenchymal stem cells therapy in acute on chronic liver failure and chronic liver disease: a systematic review and meta-analysis of randomized controlled clinical trials. Stem Cell Res. Ther. 2022;13:204. doi: 10.1186/s13287-022-02882-4. [PMC free article] [PubMed] [CrossRef] []
42. Lin BL, et al. Allogeneic bone marrow-derived mesenchymal stromal cells for hepatitis B virus-related acute-on-chronic liver failure: a randomized controlled trial. Hepatology. 2017;66:209–219. doi: 10.1002/hep.29189. [PubMed] [CrossRef] []
43. Gordon MY, et al. Characterization and clinical application of human CD34+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor. Stem Cells. 2006;24:1822–1830. doi: 10.1634/stemcells.2005-0629. [PubMed] [CrossRef] []
44. Arroyo V, et al. Acute-on-chronic liver failure in cirrhosis. Nat. Rev. Dis. Prim. 2016;2:16041. doi: 10.1038/nrdp.2016.41. [PubMed] [CrossRef] []
45. Zhang Z, et al. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J. Gastroenterol. Hepatol. 2012;27(Suppl 2):112–120. doi: 10.1111/j.1440-1746.2011.07024.x. [PubMed] [CrossRef] []
46. El-Ansary M, et al. Phase II trial: undifferentiated versus differentiated autologous mesenchymal stem cells transplantation in Egyptian patients with HCV induced liver cirrhosis. Stem Cell Rev. Rep. 2012;8:972–981. doi: 10.1007/s12015-011-9322-y. [PubMed] [CrossRef] []
47. Xu L, et al. Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: regulation of Treg/Th17 cells. J. Gastroenterol. Hepatol. 2014;29:1620–1628. doi: 10.1111/jgh.12653. [PubMed] [CrossRef] []
48. Suk KT, et al. Transplantation with autologous bone marrow-derived mesenchymal stem cells for alcoholic cirrhosis: Phase 2 trial. Hepatology. 2016;64:2185–2197. doi: 10.1002/hep.28693. [PubMed] [CrossRef] []
49. Fang X, et al. A study about immunomodulatory effect and efficacy and prognosis of human umbilical cord mesenchymal stem cells in patients with chronic hepatitis B-induced decompensated liver cirrhosis. J. Gastroenterol. Hepatol. 2018;33:774–780. doi: 10.1111/jgh.14081. [PubMed] [CrossRef] []
50. Mohamadnejad M, et al. Randomized placebo-controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis. Liver Int. 2013;33:1490–1496. doi: 10.1111/liv.12228. [PubMed] [CrossRef] []
51. Nguyen TL, et al. Autologous bone marrow mononuclear cell infusion for liver cirrhosis after the Kasai operation in children with biliary atresia. Stem Cell Res. Ther. 2022;13:108. doi: 10.1186/s13287-022-02762-x. [PMC free article] [PubMed] [CrossRef] []
52. Bai YQ, et al. Outcomes of autologous bone marrow mononuclear cell transplantation in decompensated liver cirrhosis. World J. Gastroenterol. 2014;20:8660–8666. doi: 10.3748/wjg.v20.i26.8660. [PMC free article] [PubMed] [CrossRef] []
53. Guo C, et al. Long-term outcomes of autologous peripheral blood stem cell transplantation in patients with cirrhosis. Clin. Gastroenterol. Hepatol. 2019;17:1175–1182 e1172. doi: 10.1016/j.cgh.2018.10.034. [PubMed] [CrossRef] []
54. Newsome PN, et al. Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial. Lancet Gastroenterol. Hepatol. 2018;3:25–36. doi: 10.1016/S2468-1253(17)30326-6. [PMC free article] [PubMed] [CrossRef] []
55. Spahr L, et al. Autologous bone marrow mononuclear cell transplantation in patients with decompensated alcoholic liver disease: a randomized controlled trial. PLoS ONE. 2013;8:e53719. doi: 10.1371/journal.pone.0053719. [PMC free article] [PubMed] [CrossRef] []
56. Maurice J, Manousou P. Non-alcoholic fatty liver disease. Clin. Med. 2018;18:245–250. doi: 10.7861/clinmedicine.18-3-245. [PMC free article] [PubMed] [CrossRef] []
57. Huang TD, Behary J, Zekry A. Non-alcoholic fatty liver disease: a review of epidemiology, risk factors, diagnosis and management. Intern. Med. J. 2020;50:1038–1047. doi: 10.1111/imj.14709. [PubMed] [CrossRef] []
58. Sakai Y, et al. Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy. Regen. Ther. 2021;18:97–101. doi: 10.1016/j.reth.2021.04.003. [PMC free article] [PubMed] [CrossRef] []
59. Mieli-Vergani G, et al. Autoimmune hepatitis. Nat. Rev. Dis. Primers. 2018;4:18018. doi: 10.1038/nrdp.2018.17. [PubMed] [CrossRef] []
60. Calore E, et al. Haploidentical stem cell transplantation cures autoimmune hepatitis and cerebrovascular disease in a patient with sickle cell disease. Bone Marrow Transpl. 2018;53:644–646. doi: 10.1038/s41409-017-0065-5. [PubMed] [CrossRef] []
61. Vento S, Cainelli F, Renzini C, Ghironzi G, Concia E. Resolution of autoimmune hepatitis after bone-marrow transplantation. Lancet. 1996;348:544–545. doi: 10.1016/S0140-6736(05)64700-9. [PubMed] [CrossRef] []
62. Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D. Autoimmmune hepatitis. Cell Mol. Immunol. 2022;19:158–176. doi: 10.1038/s41423-021-00768-8. [PMC free article] [PubMed] [CrossRef] []
63. Wang L, et al. Pilot study of umbilical cord-derived mesenchymal stem cell transfusion in patients with primary biliary cirrhosis. J. Gastroenterol. Hepatol. 2013;28(Suppl 1):85–92. doi: 10.1111/jgh.12029. [PubMed] [CrossRef] []
64. Wang L, et al. Allogeneic bone marrow mesenchymal stem cell transplantation in patients with UDCA-resistant primary biliary cirrhosis. Stem Cells Dev. 2014;23:2482–2489. doi: 10.1089/scd.2013.0500. [PubMed] [CrossRef] []
65. Martel-Pelletier J, et al. Osteoarthritis. Nat. Rev. Dis. Prim. 2016;2:16072. doi: 10.1038/nrdp.2016.72. [PubMed] [CrossRef] []
66. Olsson S, Akbarian E, Lind A, Razavian AS, Gordon M. Automating classification of osteoarthritis according to Kellgren-Lawrence in the knee using deep learning in an unfiltered adult population. BMC Musculoskelet. Disord. 2021;22:844. doi: 10.1186/s12891-021-04722-7. [PMC free article] [PubMed] [CrossRef] []
67. Mahmoudian A, Lohmander LS, Mobasheri A, Englund M, Luyten FP. Early-stage symptomatic osteoarthritis of the knee—time for action. Nat. Rev. Rheumatol. 2021;17:621–632. doi: 10.1038/s41584-021-00673-4. [PubMed] [CrossRef] []
68. Kubsik-Gidlewska A, et al. CD34+ stem cell treatment for knee osteoarthritis: a treatment and rehabilitation algorithm. J. Rehabil. Med Clin. Commun. 2018;3:1000012. doi: 10.2340/20030711-1000012. [PMC free article] [PubMed] [CrossRef] []
69. Jevotovsky DS, Alfonso AR, Einhorn TA, Chiu ES. Osteoarthritis and stem cell therapy in humans: a systematic review. Osteoarthr. Cartil. 2018;26:711–729. doi: 10.1016/j.joca.2018.02.906. [PubMed] [CrossRef] []
70. Wiggers TG, Winters M, Van den Boom NA, Haisma HJ, Moen MH. Autologous stem cell therapy in knee osteoarthritis: a systematic review of randomised controlled trials. Br. J. Sports Med. 2021;55:1161–1169. doi: 10.1136/bjsports-2020-103671. [PubMed] [CrossRef] []
71. Han SB, Seo IW, Shin YS. Intra-articular injections of hyaluronic acid or steroids associated with better outcomes than platelet-rich plasma, adipose mesenchymal stromal cells, or placebo in knee osteoarthritis: a network meta-analysis. Arthroscopy. 2021;37:292–306. doi: 10.1016/j.arthro.2020.03.041. [PubMed] [CrossRef] []
72. Bastos R, et al. Intra-articular injections of expanded mesenchymal stem cells with and without addition of platelet-rich plasma are safe and effective for knee osteoarthritis. Knee Surg. Sports Traumatol. Arthrosc. 2018;26:3342–3350. doi: 10.1007/s00167-018-4883-9. [PubMed] [CrossRef] []
73. Molnar, V. et al. Mesenchymal stem cell mechanisms of action and clinical effects in osteoarthritis: a narrative review. Genes13, 949 (2022). [PMC free article] [PubMed]
74. Barisic S, Childs RW. Graft-versus-solid-tumor effect: from hematopoietic stem cell transplantation to adoptive cell therapies. Stem Cells. 2022;40:556–563. doi: 10.1093/stmcls/sxac021. [PMC free article] [PubMed] [CrossRef] []
75. Mello MM, Brennan TA. The controversy over high-dose chemotherapy with autologous bone marrow transplant for breast cancer. Health Aff. (Millwood) 2001;20:101–117. doi: 10.1377/hlthaff.20.5.101. [PubMed] [CrossRef] []
76. Sissung TM, Figg WD. Stem cell clinics: risk of proliferation. Lancet Oncol. 2020;21:205–206. doi: 10.1016/S1470-2045(19)30787-9. [PubMed] [CrossRef] []
77. Fu, X. et al. Mesenchymal stem cell migration and tissue repair. Cells8, 784 (2019). [PMC free article] [PubMed]
78. Zachar L, Bacenkova D, Rosocha J. Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment. J. Inflamm. Res. 2016;9:231–240. doi: 10.2147/JIR.S121994. [PMC free article] [PubMed] [CrossRef] []
79. de Araujo Farias V, Carrillo-Galvez AB, Martin F, Anderson P. TGF-beta and mesenchymal stromal cells in regenerative medicine, autoimmunity and cancer. Cytokine Growth Factor Rev. 2018;43:25–37. doi: 10.1016/j.cytogfr.2018.06.002. [PubMed] [CrossRef] []
80. Ding W, et al. Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch. Blood. 2010;116:2984–2993. doi: 10.1182/blood-2010-02-269894. [PMC free article] [PubMed] [CrossRef] []
81. Ritter E, et al. Breast cancer cell-derived fibroblast growth factor 2 and vascular endothelial growth factor are chemoattractants for bone marrow stromal stem cells. Ann. Surg. 2008;247:310–314. doi: 10.1097/SLA.0b013e31816401d5. [PubMed] [CrossRef] []
82. Cronwright G, et al. Cancer/testis antigen expression in human mesenchymal stem cells: down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression. Cancer Res. 2005;65:2207–2215. doi: 10.1158/0008-5472.CAN-04-1882. [PubMed] [CrossRef] []
83. Aldinucci, D., Borghese, C. & Casagrande, N. The CCL5/CCR5 axis in cancer progression. Cancers12, 1765 (2020). [PMC free article] [PubMed]
84. Karnoub AE, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007;449:557–563. doi: 10.1038/nature06188. [PubMed] [CrossRef] []
85. Kucerova L, Matuskova M, Hlubinova K, Altanerova V, Altaner C. Tumor cell behaviour modulation by mesenchymal stromal cells. Mol. Cancer. 2010;9:129. doi: 10.1186/1476-4598-9-129. [PMC free article] [PubMed] [CrossRef] []
86. Schmohl KA, Muller AM, Nelson PJ, Spitzweg C. Thyroid hormone effects on mesenchymal stem cell biology in the tumour microenvironment. Exp. Clin. Endocrinol. Diabetes. 2020;128:462–468. doi: 10.1055/a-1022-9874. [PubMed] [CrossRef] []
87. Mishra PJ, et al. Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res. 2008;68:4331–4339. doi: 10.1158/0008-5472.CAN-08-0943. [PMC free article] [PubMed] [CrossRef] []
88. Liu J, Han G, Liu H, Qin C. Suppression of cholangiocarcinoma cell growth by human umbilical cord mesenchymal stem cells: a possible role of Wnt and Akt signaling. PLoS ONE. 2013;8:e62844. doi: 10.1371/journal.pone.0062844. [PMC free article] [PubMed] [CrossRef] []
89. Ho IA, et al. Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis. Stem Cells. 2013;31:146–155. doi: 10.1002/stem.1247. [PubMed] [CrossRef] []
90. Sun Z, Wang S, Zhao RC. The roles of mesenchymal stem cells in tumor inflammatory microenvironment. J. Hematol. Oncol. 2014;7:14. doi: 10.1186/1756-8722-7-14. [PMC free article] [PubMed] [CrossRef] []
91. Rhee KJ, Lee JI, Eom YW. Mesenchymal stem cell-mediated effects of tumor support or suppression. Int. J. Mol. Sci. 2015;16:30015–30033. doi: 10.3390/ijms161226215. [PMC free article] [PubMed] [CrossRef] []
92. Liang W, et al. Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines. Cell Mol. Biol. Lett. 2021;26:3. doi: 10.1186/s11658-020-00246-5. [PMC free article] [PubMed] [CrossRef] []
93. Hmadcha A, Martin-Montalvo A, Gauthier BR, Soria B, Capilla-Gonzalez V. Therapeutic potential of mesenchymal stem cells for cancer therapy. Front. Bioeng. Biotechnol. 2020;8:43. doi: 10.3389/fbioe.2020.00043. [PMC free article] [PubMed] [CrossRef] []
94. Cao GD, et al. The oncolytic virus in cancer diagnosis and treatment. Front. Oncol. 2020;10:1786. doi: 10.3389/fonc.2020.01786. [PMC free article] [PubMed] [CrossRef] [] Retracted
95. Melen GJ, et al. Influence of carrier cells on the clinical outcome of children with neuroblastoma treated with high dose of oncolytic adenovirus delivered in mesenchymal stem cells. Cancer Lett. 2016;371:161–170. doi: 10.1016/j.canlet.2015.11.036. [PubMed] [CrossRef] []
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